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Matt Hancock will address the nation today as hopes grow that a vaccine will be rolled out in December.
It comes following a drop in coronavirus cases across England following the national lockdown, which comes to an end this week.
Infections fell by a third across the country during November, research by Imperial College revealed.
Experts also estimated that the vital R-rate had fell below 1, meaning that the virus was shrinking.
Mr Hancock said: “He said: "Thanks to the huge efforts of the public over the last few weeks, we have been able to get the virus more under control.
"This latest data shows we must keep our resolve and we cannot afford to take our foot off the pedal just yet, despite the encouraging fall in cases and progress on vaccines.
"The next few weeks and months are the busiest time of year for our NHS, so it's vital we all continue to follow new local restrictions, wash our hands, wear a face covering and observe social distancing."
It is expected he will take to the usual podium at about 5pm this afternoon.
Reports on Monday suggest the NHS is preparing for a rollout of the Covid vaccine "within days" – with some suggesting as early as Wednesday, Birmingham Mail reported.
Some of the biggest hotspots in England saw the biggest improvements in driving new infections down, according to the results.
The findings were based on research done by swabbing more than 100,000 people between November 13 and 24, the middle of the second national lockdown.
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Results suggested that there had actually been a 30% fall between the last study and the most recent research.
Before that cases were accelerating, the BBC reported, roughly doubling every nine days.
But new cases are now coming down, more slowly than they increased, halving every 37 days.
The UK has stocked up on 2 million doses of a promising vaccine candidate as it gears up to launch the widespread jab programme within days.
Officials hope to be one of the first countries in the world to start vaccinating against Covid-19.
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The UK had Europe’s deadliest outbreak, with more than 58,000 deaths related to the disease.
The Department of Health said Sunday it had increased its order for a vaccine developed by U.S. firm Moderna from 5 million to 7 million doses, enough for 3.5 million people.
Britain has ordered 40 million doses of the Pfizer/BioNTech vaccine and 100 million doses of the Oxford/AstraZeneca vaccine.
Rolling out the Pfizer/BioNTech vaccine may pose the greatest challenge as it needs to be stored at minus 70C, raising potential difficulties with transport and storage.
Hospitals in England have been told they could receive the first doses of the Pfizer shot as early as the week of Dec. 7 if it receives approval, the Guardian and Financial Times reported.
It comes as a further 479 deaths yesterday within 28 days of a positive test were reported in the UK, bringing the total to 58,030.
There were also a further 15,871 positive cases registered in the 24 hours from Sunday, official data said.
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